Uses and Examples of SystemModeler

Insulin Signaling: Modeling a Biochemical Process

Insulin signaling in fat cells plays an important role in controlling the glucose level in the body. Insulin binding to receptors causes them to phosphorylate, transducing the insulin signal into the cells, controlling glucose uptake.

To run this example, you'll need

SystemModeler 3 and Mathematica 8 or 9.

Please make a selection:

Model Biochemical Processes

Model insulin signals with the included BioChem library.

Visualize Sensitivity to Parameters

Easily identify the parameters that affect the phosphorylation most when changed.

         
 
Variation of the IRS1 phosphorylation when varying each parameter
 
   
   
         

Compare Simulations Instantly

Compare how different real-world parameter combinations affect IRS1 (Insulin Receptor Substrate 1) phosphorylation.