Since first working with Mathematica 2.2 in 1996, most of Grigory Fridman's research publications have been produced using Mathematica. He began teaching his "Programming in Mathematica" course in 2000. His courses "Numerical Methods" and "Higher and Linear Algebra" are also heavily based on Mathematica. His research projects include optimal overbooking modeling for airline revenue management, demand-driven scheduling of movies in a multiplex, and implementing Mathematica in higher education.

Fridman is an Adjunct Professor in the Department of Applied Mathematics and Mathematica Modeling at Saint Petersburg State Marine Technical University and Professor, Chair of Department of Economical Cybernetics and Mathematical Methods for Economics, at Saint Petersburg State University of Economics and Finance.