Karl Isensee has been a member of the Wolfram Technology Group since October 2011. In his PhD work he used Mathematica to reduce, analyze, and visualize data from the Spitzer Space Telescope and Chandra X-ray Observatory. His analysis was included in a publication for The Astrophysical Journal.

Isensee has teaching experience as a physics lab instructor at Carleton College. He has also lectured in astronomy at the University of Minnesota.