
The use of liver-specific contrast agents in combination with magnetic resonance imaging (MRI) has recently emerged as a non-invasive approach to assess liver function. Here, we create a pharmacokinetic model to describe the distribution and transfer rates of contrast agent between different parts of the body. Using MRI data, the model is then calibrated to investigate the quantitative difference between a non-diseased population and diseased patients suffering from liver fibrosis stage 4.
Create Compartmental Biological Models
Create a compartmental model with custom-designed components that describe the pharmacokinetics of the contrast agent.
Perform Monte Carlo simulations
Use Mathematica to define probability distributions corresponding to non-diseased and diseased parameters for contrast-agent uptake in the liver.
Dynamically visualize contrast agent fluxes
Use dynamic diagrams to visualize the comparative amounts of contrast agent flowing between the different compartments.
Programmatically control simulations
Use WSMSimulate to simulate multiple parameter samples from the non-diseased and diseased populations and compare the contrast agent concentrations in the liver.
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