Houston Methodist is a leading academic medical center that takes a multidisciplinary approach to changing the face of medicine. Doctors Cristini, Butner and Wang are a team of engineer scientists at the Houston Methodist Research Institute who use mathematical modeling to study biological problems, with a special focus on disease progression and treatment. They design and implement mathematical descriptions of the key biophysical phenomena within the tumor microenvironment. They are currently working to establish methods to use mathematical modeling to predict cancer-patient response to immune checkpoint inhibitor immunotherapy. Mathematica has played a key role in this process, allowing them to rapidly implement and update model versions, perform testing and optimization, and conduct extensive analysis on large sets of patient data.
Award accepted by Dr. Joseph D. Butner, faculty fellow, Mathematics in Medicine program; Dr. Vittorio Cristini, professor and director, Mathematics in Medicine program; and Dr. Zhihui Wang, research scientist and associate professor, Mathematics in Medicine program.